Pseudo-monoclonal gammopathy due to autoimmune disease: a case report.
Wenhui LeiGuojin WangJia SongJing GuanZonghong ShaoRong FuPublished in: The Journal of international medical research (2019)
Hyperglobulinemia is a common manifestation of plasma cell disease, and it is sometimes caused by autoimmune diseases (AIDs). We report an uncommon presentation of hyperglobulinemia, with a high amount of plasma cells in bone marrow, pancytopenia, hematemesis, and splenomegaly in an 18-year-old woman. Some examinations were performed to determine the diagnosis, including serum protein electrophoresis, immunofixation electrophoresis, the free light chain assay, abdominal enhanced computed tomography (CT) and CT venography, and positron-emission tomography-CT. The patient was finally diagnosed with AID. Considerable improvement in her symptoms was observed after immunosuppressive therapy. Findings in this case highlight that not only differentiation of hyperglobulinemia caused by monoclonal or polyclonal immunoglobulin, but also AIDs, need to be considered to exclude non-Hodgkin's lymphoma and plasma cell disease.
Keyphrases
- computed tomography
- positron emission tomography
- dual energy
- image quality
- bone marrow
- contrast enhanced
- case report
- magnetic resonance imaging
- single cell
- pet imaging
- cell therapy
- pet ct
- mesenchymal stem cells
- induced apoptosis
- antiretroviral therapy
- multiple sclerosis
- small molecule
- magnetic resonance
- cell cycle arrest
- physical activity
- cell death
- replacement therapy