The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate.
Zili LiFang FangYuting LongQian ZhaoXiaotong WangZhen YeTianqing MengXiuli GuWenpei XiangChengliang XiongHong-Gang LiPublished in: Cell & bioscience (2022)
Our results show that TETs-mediated oxidation of 5-methylcytosine modulates the NODAL signaling pathway and its downstream genes, NANOG and SOX17, by promoting demethylation in opposition to DNMT3B-mediated methylation, suggesting that the epigenetic balance of DNA methylation and demethylation in key genes plays a fundamental role in early hPGC specification.