The balance between NANOG and SOX17 mediated by TET proteins regulates specification of human primordial germ cell fate.

Zili LiFang FangYuting LongQian ZhaoXiaotong WangZhen YeTianqing MengXiuli GuWenpei XiangChengliang XiongHong-Gang Li

Published in: Cell & bioscience (2022)

Our results show that TETs-mediated oxidation of 5-methylcytosine modulates the NODAL signaling pathway and its downstream genes, NANOG and SOX17, by promoting demethylation in opposition to DNMT3B-mediated methylation, suggesting that the epigenetic balance of DNA methylation and demethylation in key genes plays a fundamental role in early hPGC specification.

Keyphrases

rectal cancer
dna methylation
cell fate
genome wide
signaling pathway
gene expression
stem cells
transcription factor
endothelial cells
copy number
squamous cell carcinoma
neoadjuvant chemotherapy
genome wide identification
pi k akt
radiation therapy
cell proliferation