Statin administration ameliorates ischemia-induced overactive bladder with improvement of blood flow and anti-inflammatory effects in rats.

Yuichi Ishizuka Yohei Satake Shingo Kimura Shinichi Yamashita Naoki Kawamorita Akihiro Ito

Published in: Neurourology and urodynamics (2024)

The present results suggest that statins are effective in OAB caused by arteriosclerosis and ischemia. The mechanism of their effects involves improved bladder blood flow and decreased bladder inflammation.

Keyphrases

blood flow
spinal cord injury
cardiovascular disease
oxidative stress
diabetic rats
high glucose
urinary tract
coronary artery disease
mouse model
drug induced
endothelial cells