PEGylated AIEgen molecular probe for hypoxia-mediated tumor imaging and photodynamic therapy.

Jun LiWei LiuZuhao LiYingcai HuJinfeng YangJishan Li

Published in: Chemical communications (Cambridge, England) (2021)

We report a novel PEGylated aggregation-induced emission luminogen (AIEgen) molecular probe for hypoxia-mediated tumor imaging and photodynamic therapy by linking a PEG chain to the AIE-active photosensitizer via a hypoxia-sensitive azo group.

Keyphrases

photodynamic therapy
fluorescence imaging
living cells
high resolution
endothelial cells
quantum dots
single molecule
drug delivery
fluorescent probe
mass spectrometry