Determinants of sputum culture conversion time in multidrug-resistant tuberculosis patients in ALERT comprehensive specialized hospital, Addis Ababa, Ethiopia: A retrospective cohort study.
Muluye AbebeAbay AtnafuMelaku TilahunNejmia SeroSebsibe NewayMekdes Alemu TolaGetachew TesfayeAdane MihretKidist BoboshaChengsong WanPublished in: PloS one (2024)
The median time to sputum culture conversion for HIV positive was found to be 61 days in our study. Notably, patients with a history of previous anti-tuberculosis treatment, HIV-negative status, and higher bacillary load at baseline exhibited delayed culture conversion. These findings underscore the importance of considering such patient characteristics in the management of MDR-TB cases, as tailored interventions and close monitoring may lead to more favorable treatment outcomes. By identifying individuals with these risk factors early in the treatment process, healthcare providers can implement targeted strategies to optimize patient care and improve overall treatment success rates in MDR-TB management programs.
Keyphrases
- mycobacterium tuberculosis
- hiv positive
- multidrug resistant
- healthcare
- antiretroviral therapy
- risk factors
- pulmonary tuberculosis
- cystic fibrosis
- hiv aids
- human immunodeficiency virus
- public health
- ejection fraction
- south africa
- hiv infected
- combination therapy
- palliative care
- physical activity
- drug delivery
- escherichia coli
- patient reported outcomes
- cancer therapy
- drug induced