Levels of Angiopoietin 2 Are Predictive for Mortality in Patients Infected With Yellow Fever Virus.
Cornelia A M van de WegMateus Vailant ThomazellaMariana P MarmoratoCarolina A CorreiaJuliana Z C DiasAlvino MaestriLuiz G F A B E ZanellaNatalia B CerqueiraAlvina C FélixCarlos H V MoreiraRenata BuccheriPriscilla R CostaEsper G KallásPublished in: The Journal of infectious diseases (2024)
In 2018 there was a large yellow fever outbreak in São Paulo, Brazil, with a high fatality rate. Yellow fever virus can cause, among other symptoms, hemorrhage and disseminated intravascular coagulation, indicating a role for endothelial cells in disease pathogenesis. Here, we conducted a case-control study and measured markers related to endothelial damage in plasma and its association with mortality. We found that angiopoietin 2 is strongly associated with a fatal outcome and could serve as a predictive marker for mortality. This could be used to monitor severe cases and provide care to improve disease outcome.
Keyphrases
- endothelial cells
- cardiovascular events
- end stage renal disease
- healthcare
- ejection fraction
- risk factors
- chronic kidney disease
- newly diagnosed
- oxidative stress
- peritoneal dialysis
- prognostic factors
- cardiovascular disease
- quality improvement
- high glucose
- physical activity
- depressive symptoms
- vascular endothelial growth factor
- sleep quality