Sex-Specific Skeletal Muscle Gene Expression Responses to Exercise Reveal Novel Direct Mediators of Insulin Sensitivity Change.
S MaM C MorrisM J HubalL M RossK M HuffmanC G VannN MooreE R HauserA BarejaR JiangE KummerfeldM D BarberioJ A HoumardW B BennettJ L JohnsonJ A TimmonsG BroderickV B KrausC F AliferisWilliam E KrausPublished in: medRxiv : the preprint server for health sciences (2024)
The signaling pathways mediating Si improvements from aerobic exercise differed by sex and were further distinguished by exercise intensity and amount. Transcriptional adaptations in skeletal muscle related to Si improvements appear to be causally linked to estrogen and PKC signaling, with EGFR and other identified targets emerging as potential skeletal muscle-specific drug targets to mimic the beneficial effects of exercise on Si.
Keyphrases
- skeletal muscle
- high intensity
- gene expression
- insulin resistance
- resistance training
- physical activity
- room temperature
- small cell lung cancer
- signaling pathway
- dna methylation
- transcription factor
- emergency department
- epidermal growth factor receptor
- oxidative stress
- body composition
- cell proliferation
- drug induced
- ionic liquid
- induced apoptosis
- heat shock