Precision-medicine findings from the FACE-SZ cohort to develop motivation-enhancing programs in real-world schizophrenia.
Théo KorchiaMaud TastevinPierre-Louis Sunhary de VervilleRidha JooberChristelle Andrieu-HallerMélanie FaugereOphélia GodinDamien Etchecopar-EtchartFabrice BernaBruno AouizerateDelphine CapdevielleIsabelle ChereauJulie Clauss-KobayashiNathalie CoulonJean-Michel DoreyCaroline DubertretJulien DubreucqJasmina MalletDavid MisdrahiChristine PasserieuxRomain ReyFrank SchürhoffAndrei SzokeMathieu UrbachMarion LeboyerPierre Michel LlorcaChristophe LançonRaphaelle RichieriLaurent BoyerGuillaume FondPublished in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2022)
Motivation deficits are frequent and remain persistent unmet need in real-world schizophrenia that should be addressed in future guidelines. Based on our results, literature and clinical experience, we recommend to address in priority major depression, sleep, suicide, positive symptoms (when present and as early as possible) and medication adherence to improve motivation deficits of schizophrenia.