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Alteration of basilar artery rho-kinase and soluble guanylyl cyclase protein expression in a rat model of cerebral vasospasm following subarachnoid hemorrhage.

Chih-Jen WangPei-Yu LeeBin-Nan WuShu-Chuan WuJoon-Khim LohHung-Pei TsaiChia-Li ChungNeal F KassellAij-Lie Kwan
Published in: BioMed research international (2014)
These results demonstrate that the rhoA/rho-kinase and sGC/cGMP/PKG pathways play pivotal roles in cerebral vasospasm after SAH. It also shows that ECE inhibition is an effective strategy for the treatment of this disease.
Keyphrases
  • subarachnoid hemorrhage
  • protein kinase
  • brain injury
  • cerebral ischemia
  • nitric oxide
  • tyrosine kinase
  • smooth muscle