Existing fluid responsiveness studies using the mini-fluid challenge may be misleading: Methodological considerations and simulations.
Johannes EnevoldsenThomas W L ScheerenJonas M BergSimon Tilma VistisenPublished in: Acta anaesthesiologica Scandinavica (2021)
Many existing MFC studies are likely overestimating the classification accuracy of the MFC. This should be considered before adopting the MFC into clinical practice. A better study design includes a second, independent measurement of stroke volume after the MFC. This measurement serves as reference for the response to the subsequent fluid challenge.