In conclusion, adding interleukin 6 to MM cell culture promotes the in vitro growth of myeloma cells and enhances the successful application of FISH technique. A comprehensive FISH probe set investigating high, intermediate and low-risk cytogenetic abnormalities is needed for accurate risk stratification. Hyperdiploid-myeloma is a favorable risk genetic subtype of MM associated with rapid response to therapy compared to patients having del 17p, t(4;14), and other 14q rearrangements rather than t(11;14) and t(6;14).
Keyphrases
- multiple myeloma
- newly diagnosed
- end stage renal disease
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- cell cycle arrest
- prognostic factors
- genome wide
- high resolution
- single molecule
- stem cells
- gene expression
- single cell
- mesenchymal stem cells
- mass spectrometry
- living cells
- quantum dots
- cell proliferation
- signaling pathway
- cell death