Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.
Yan LanTsz-Lun YeungHui HuangAnsgar A WegenerSomdutta SahaMira Toister-AchituvMolly H JenkinsLi-Ya ChiuAdam LazorchakOhad TarcicHong WangJin QiGeorge LockeDoron KalimiGuozhong QinBo MarelliHuakui YuAlec W GrossMelissa G DernerMaria SolovievMathieu BotteAroop SircarHong MaVanita D SoodDong ZhangFeng JiangKin-Ming LoPublished in: Journal for immunotherapy of cancer (2022)
BA more effectively blocks TGF-β by targeting TGF-β trap to the tumor via PD-L1 binding. Such colocalized targeting elicits distinct and superior antitumor responses relative to single agent combination therapy.