Investigation of Pectin-Hydroxypropyl Methylcellulose-Coated Floating Beads for Pulsatile Release of Piroxicam.

The study revealed that optimized floating pulsatile beads coated with pectin-HPMC can efficiently retain piroxicam in an acidic medium and that there is pulsed release in an alkaline medium after a lag time. It also showed that the beads prepared can potentially be used for chronotherapeutic treatment of the disease associated with early morning inflammation.