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Preparation and Analysis of Functional Silicone Hydrogel Lenses Containing ZrO₂ and Antimony Tin Oxide Nanoparticles.

Su-Mi ShinA-Young Sung
Published in: Journal of nanoscience and nanotechnology (2021)
This study prepared silicone hydrogel ophthalmic lenses using 2-hydroxyethylmethacrylate (HEMA), synthesized silicone monomer (SID), dimethylarsinic acid (DMA), N-hydroxyethyl acrylamide (HEA), ethylene glycol dimethacrylate (a crosslinking agent, EGDMA), and azobisisobutyronitrile (an initiator, AIBN). Also, Zirconium oxide (ZrO₂), antimony tin oxide (ATO) nanoparticles were added to the silicone hydrogel material to analyze the characteristics of the nanoparticles. The mixture was heated at 130 °C for 2 hours to produce the ophthalmic contact lens by cast mould method. As a result, the manufactured silicone hydrogel lens was prepared having high oxygen permeability and tensile strength while satisfying the basic requirements of ophthalmic hydrogel lens materials. Also, the addition of ZrO₂ NPs increased tensile strength of the manufactured lens, and ATO NPs were found to improve wettability. Therefore, ZrO₂ and ATO nanoparticles can be used effectively as additives for functional ophthalmic silicone hydrogel lenses.
Keyphrases
  • oxide nanoparticles
  • drug delivery
  • hyaluronic acid
  • cataract surgery
  • wound healing
  • tissue engineering
  • endothelial cells
  • mass spectrometry
  • high resolution
  • liquid chromatography