IRS2 Signaling Protects Against Stress-Induced Arrhythmia by Maintaining Ca 2+ Homeostasis.

Qian Shi Jinxi Wang Hamza Malik Xuguang Li Jennifer Streeter Jacob Sharafuddin Eric T Weatherford David SteinYuval ItanBiyi Chen Duane D Hall Long-Sheng Song E Dale Abel

Published in: Circulation (2024)

Cardiac IRS2 inhibits sympathetic stress-induced AKT/NOS3/CaMKII/RyR2 overactivation and calcium-dependent arrhythmogenesis. This novel IRS2 signaling axis, essential for maintaining cardiac calcium homeostasis under stress, presents a promising target for developing new antiarrhythmic therapies.

Keyphrases

stress induced
left ventricular
signaling pathway
cell proliferation
catheter ablation
nitric oxide synthase
heart failure
atrial fibrillation