A small molecule inhibitor of the perinucleolar compartment, ML246, attenuates growth and spread of ovarian cancer.

Margaux J KanisWenan QiangMario PinedaKruti P ManiarJ Julie Kim

Published in: Gynecologic oncology research and practice (2018)

PNC's are present in ovarian cancer cells and treatment with ML246 decreases invasion in vitro and tumor growth and spread in vivo. Additional studies are warranted to determine the efficacy of ML246 as an inhibitor of metastatic disease in ovarian cancer and to determine its precise mechanism of action.

Keyphrases

small molecule
squamous cell carcinoma
small cell lung cancer
protein protein
replacement therapy