ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers.
Reinaldo B OriáRaul S FreitasCássia R RoqueJosé Carlos R NascimentoAna Paula SilvaJoão O MalvaRichard L GuerrantMichael P VitekPublished in: Pharmaceutics (2023)
Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein's LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of enteric infections and malnutrition is closely related to environmental-driven enteric dysfunction early in life, and such chronic inflammatory conditions may blunt the developmental trajectories of children with worrisome and often irreversible physical and cognitive faltering. This window of time for microbiota maturation and brain plasticity is key to protecting cognitive domains, brain health, and achieving optimal/full developmental potential. This review summarizes the potential role of promising apoE mimetic peptides to improve the function of the gut-brain axis, including targeting the blood-brain barrier in children afflicted with malnutrition and enteric infections.
Keyphrases
- brain injury
- cerebral ischemia
- resting state
- cognitive decline
- white matter
- oxidative stress
- high fat diet
- subarachnoid hemorrhage
- functional connectivity
- healthcare
- young adults
- public health
- mental health
- human health
- amino acid
- multiple sclerosis
- type diabetes
- mild cognitive impairment
- blood brain barrier
- skeletal muscle
- drug delivery
- health information
- protein protein