β-Cell Autophagy Pathway and Endoplasmic Reticulum Stress Regulating-Role of Liposomal Curcumin in Experimental Diabetes Mellitus: A Molecular and Morphometric Study.

Safaa I KhaterMohamed F DowidarAya E Abdel-AzizTarek KhamisNaief DahranLeena S AlqahtaniMohamed M M MetwallyAl-Sayed Al-Hady Abd-ElrahamnMohammed A AlsieniManal E AlosaimiMaram H AbduljabbarAmany Abdel-Rahman Mohamed

Published in: Antioxidants (Basel, Switzerland) (2022)

LP-CUR ameliorates β-cell damage by targeting the autophagy pathway with the regulatory miRNAs miR-137 and miR-29b, which functionally abrogates ER stress in β-cells. This study presents a new therapeutic target for managing type I diabetes using miR-137 and miR-29b.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
oxidative stress
cell proliferation
long non coding rna
signaling pathway
cell death
single cell
type diabetes
cell therapy
long noncoding rna
cardiovascular disease
adipose tissue
metabolic syndrome
cell cycle arrest
glycemic control
insulin resistance
weight loss