The association between local atherosclerosis of the prostatic artery and benign prostatic enlargement in humans: Putative mechanism of chronic ischemia for prostatic enlargement.
Nobuhiro HagaHidenori AkaihataJunya HataKen AikawaTomohiko YanagidaKanako MatsuokaTomoyuki KoguchiSeiji HoshiSoichiro OgawaMasao KataokaYuichi SatoKei IshibashiOsamu SuzukiYuko HashimotoYoshiyuki KojimaPublished in: The Prostate (2018)
In human surgical specimens, there is evidence that local atherosclerosis of the prostatic artery is significantly associated with prostate size. Given the molecular evidence provided in this study, the putative mechanism for this relationship is that chronic ischemia induced upregulation of oxidative stress pathways, leading to BPE.
Keyphrases
- benign prostatic hyperplasia
- radical prostatectomy
- oxidative stress
- prostate cancer
- diabetic rats
- endothelial cells
- cardiovascular disease
- high glucose
- drug induced
- cell proliferation
- dna damage
- signaling pathway
- type diabetes
- induced pluripotent stem cells
- induced apoptosis
- single molecule
- ischemia reperfusion injury
- heat stress