Pulmonary artery embolism: comprehensive transcriptomic analysis in understanding the pathogenic mechanisms of the disease.
Leszek GromadzińskiŁukasz PauksztoEwa LepiarczykAgnieszka SkowrońskaAleksandra LipkaKarol G MakowczenkoElżbieta Łopieńska-BiernatJan P JastrzębskiPiotr HolakMichał SmolińskiMarta MajewskaPublished in: BMC genomics (2023)
The findings of this research provide the first thorough investigation of the changes in the gene expression profile of PA affected by an embolus. Evidence from this study suggests that the disturbed homeostasis in the biosynthesis of proteins in the endoplasmic reticulum plays a major role in the pathogenesis of PE.