Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.
Robert A PowerStacy SteinbergGyda BjornsdottirCornelius A RietveldAbdel AbdellaouiMichel M NivardMagnus JohannessonTessel E GaleslootJouke J HottengaGonneke WillemsenDavid CesariniDaniel J BenjaminPatrik K E MagnussonFredrik UllénHenning TiemeierAlbert HofmanFrank J A van RooijG Bragi WaltersEngilbert SigurdssonThorgeir E ThorgeirssonAndres IngasonAgnar HelgasonAugustine KongLambertus A KiemeneyPhilipp KoellingerDorret I BoomsmaDaniel GudbjartssonHreinn StefanssonKari StefanssonPublished in: Nature neuroscience (2015)
We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10(-6) and 3.8 × 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.