AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts.

Jennifer Maries Go YapTakashi UedaYoshihiro KanemitsuNorihisa TakedaKensuke FukumitsuSatoshi FukudaTakehiro UemuraTomoko TajiriHirotsugu OhkuboKen MaenoYutaka ItoTestsuya OguriShinya UgawaAkio Niimi

Published in: Respiratory research (2021)

We found that AITC exerts protective effect on TGF-β1-induced α-SMA induction by activating ERK1/2 MAPK and NRF2/HO-1 pathways in lung fibroblasts. It also overcomes corticosteroids insensitivity in TGF-β1-induced α-SMA induction. TRPA1 antagonist modulates the suppressive effect, but not prevent it. AITC and TRPA1 antagonist may be therapeutic agents in treating chronic respiratory diseases.

Keyphrases

signaling pathway
pi k akt
oxidative stress
diabetic rats
transforming growth factor
high glucose
epithelial mesenchymal transition
drug induced
cell proliferation
extracellular matrix
endothelial cells