Whole-Genome Comparative and Pathogenicity Analysis of Salmonella enterica subsp. enterica Serovar Rissen.
Aiping ZhouJun LiZhihong XuJinjing NiJian GuoYu-Feng YaoWenjuan WuPublished in: G3 (Bethesda, Md.) (2020)
Salmonella are a type of bacteria known to cause food-borne illness. Their host range varies widely, and their susceptibility to the host determines its pathogenicity. Salmonella enterica serovar Rissen (S Rissen) is a widely distributed serotype; however, its virulence and pathogenicity are poorly understood. In this study, the pathogenicity and antibiotic resistance of a representative S Rissen isolate were investigated. The cell model results showed that S Rissen preferred to replicate in human macrophage cells U937 compared to murine macrophage cells RAW264.7, suggesting that it has a level of host adaptability. Genome sequencing and comparison analysis revealed that the distribution and nonsynonymous single nucleotide polymorphisms of virulence factors in S Rissen were similar to those in S Typhi rather than to those in S Typhimurium. Taken together, our results suggest that although S Rissen is a common serotype distributed in swine herds, pork and chicken products, it has strong ability to infect humans.
Keyphrases
- biofilm formation
- listeria monocytogenes
- escherichia coli
- induced apoptosis
- pseudomonas aeruginosa
- single cell
- cell cycle arrest
- staphylococcus aureus
- antimicrobial resistance
- adipose tissue
- endothelial cells
- dengue virus
- cell death
- gene expression
- klebsiella pneumoniae
- signaling pathway
- dna methylation
- stem cells
- cystic fibrosis
- oxidative stress
- genome wide
- mesenchymal stem cells
- mass spectrometry
- cell proliferation
- induced pluripotent stem cells