Necrosis of the optic nerve and chiasm with safe radiation doses: Report of two rare cases.
Kaveh Abri AghdamMostafa Soltan SanjariMohsen Khosravi FarsaniMehdi MoghaddasiAli AghajaniPublished in: European journal of ophthalmology (2021)
This is the second case report of RION in a patient with a history of brain radiotherapy and concurrent chemotherapy with pemetrexed. History of chiasmal compression, concurrent use of chemotherapeutic agents, and high fraction size (despite the safety of total radiation dose) were possible contributing risk factors to develop RION in our cases. Hence, adjusting the radiation dose according to the presence of these risk factors is recommended.
Keyphrases
- risk factors
- locally advanced
- case report
- optic nerve
- rectal cancer
- squamous cell carcinoma
- small cell lung cancer
- radiation therapy
- early stage
- optical coherence tomography
- radiation induced
- white matter
- advanced non small cell lung cancer
- epidermal growth factor receptor
- multiple sclerosis
- subarachnoid hemorrhage
- functional connectivity