Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series.
Beatriz Prista-LeãoIsabel AbreuRaquel DuroAndré Silva-PintoFilipa CeiaPaulo AndradeJoana Sobrinho-SimõesMargarida TavaresJosé Manuel PereiraLurdes SantosAntónio SarmentoPublished in: Infectious disease reports (2020)
Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) is associated with relapsing multifocal skin and soft tissue infections (SSTI), necrotizing pneumonia (NP) and severe musculoskeletal infections. Epidemiology is underknown and underdiagnosis is likely. Recent travel abroad, case clustering and relapsing disease are often reported. We reviewed all cases of PVL-SA infection diagnosed at our center, and found 21 cases over a 43-month period. Most patients were adult males, had relevant travel history, reported recurrent disease and presented with SSTI. Etiologic diagnosis took up to five years; meanwhile, 42% of patients had antibiotic treatments. Draining procedures were required in 43% of patients and intensive care support in 19%. All patients recovered. Methicillin-resistance prevalence was 24%. Only 2/13 decolonized patients had posterior relapsing SSTI, both with likely infected contacts. PVL-SA infection's severity and impact are clear, even in small case series as ours. Physician awareness and active PVL-gene search are crucial for an adequate management.
Keyphrases
- staphylococcus aureus
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- multiple sclerosis
- peritoneal dialysis
- prognostic factors
- emergency department
- primary care
- soft tissue
- escherichia coli
- systemic lupus erythematosus
- intensive care unit
- patient reported outcomes
- early onset
- genome wide
- single cell
- wound healing