Influence of parameter accuracy on pharmacokinetic analysis of hyperpolarized pyruvate.
Chang-Yu SunChristopher M WalkerKeith A MitchelAradhana M VenkatesanStephen Y LaiJames A BanksonPublished in: Magnetic resonance in medicine (2017)
The accuracy and precision of kPL estimates improve substantially for peak signal-to-noise ratio above approximately 20. Accurate estimates of perfusion parameters (combinations of vb , kve , and the pyruvate vascular input function) and transmit calibration at high excitation angles have the greatest effect on the accuracy of kinetic analyses. Magn Reson Med 79:3239-3248, 2018. © 2017 International Society for Magnetic Resonance in Medicine.