Efficient DBU accelerated synthesis of 18F-labelled trifluoroacetamides.

Antonio Bermejo Gómez Miguel A Cortés GonzálezMarvin LübckeMagnus J JohanssonChrister HalldinKálmán J SzabóMagnus Schou

Published in: Chemical communications (Cambridge, England) (2018)

Nucleophilic 18F-fluorination of bromodifluoromethyl derivatives was performed using [18F]Bu4NF in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This novel procedure provided a diverse set of [18F]trifluoroacetamides in good to excellent radiochemical conversions. A mechanism where DBU acts as organomediator in this transformation is proposed.

Keyphrases

signaling pathway
lps induced
pi k akt
minimally invasive
oxidative stress
inflammatory response