Alpha-1 antitrypsin deficiency as a common treatable mechanism in chronic respiratory disorders and for conditions different from pulmonary emphysema? A commentary on the new European Respiratory Society statement.
Andrea GramegnaStefano AlibertiMarco ConfalonieriAngelo CorsicoLuca RicheldiCarlo VancheriFrancesco BlasiPublished in: Multidisciplinary respiratory medicine (2018)
Over the past years, AATD has been interpreted as a common mechanism of inflammatory disequilibrium and tissue damage across different conditions. Future research is gradually pointing toward this new paradigm by expanding the evidence of the role of AAT as a potent immunomodulatory and anti-inflammatory drug in conditions different from pulmonary emphysema.