Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
Kevin R BersellTao YangJonathan D MosleyAndrew M GlazerAndrew T HaleDmytro O KryshtalKyungsoo KimJeffrey D SteimleJonathan D BrownJoe-Elie SalemCourtney C CampbellCharles C HongQuinn S WellsAmanda N JohnsonLaura ShortMarcia A BlairElijah R BehrEvmorfia PetropoulouYalda JamshidiMark D BensonMichelle J KeyesDebby NgoRamachandran S VasanQiong YangRobert E GersztenChristian ShafferShan ParikhQuanhu ShengPrince J KannankerilIvan P MoskowitzJohn D YorkThomas J WangBjörn C KnollmannDan M RodenPublished in: Circulation (2022)
variant as a cause of BrS, but also reveal a new general transcriptional mechanism of arrhythmogenesis of enhanced late sodium current caused by reduced PDGF receptor-mediated PI3K signaling.