Fingolimod ameliorates acetic acid-induced ulcerative colitis: An insight into its modulatory impact on pro/anti-inflammatory cytokines and AKT/mTOR signalling.

Mirhan N MakledMarwa S SerryaAhmed R El-Sheakh

Published in: Basic & clinical pharmacology & toxicology (2022)

Fingolimod attenuated acetic acid-induced UC through its immunomodulatory effect by shifting the balance to favour anti-inflammatory cytokine production rather than pro-inflammatory cytokines and modulating the AKT/mTOR signalling.

Keyphrases

anti inflammatory
cell proliferation
multiple sclerosis
signaling pathway
ulcerative colitis
mouse model