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Failure of multiplex meningitis/encephalitis (ME) NAT during cryptococcal meningitis in solid organ recipients.

Benoît PilmisMarie-Elizabeth BougnouxRomain GueryYaye SenghorAlban Le MonnierFanny LanternierStephane BretagneAlexandre AlanioOlivier Lortholary
Published in: Transplant infectious disease : an official journal of the Transplantation Society (2020)
Cryptococcal meningitis is a severe cause of central nervous system infections among immunocompromised solid organ transplant (SOT) patients. While new diagnostic methods as multiplex meningitis/encephalitis (ME) NAT (nucleic acid test) are increasingly used as a first-line tool in hospital practice, data in HIV-negative patients including SOT remain scarce. We report here false-negative results of multiplex NAT among SOT patients with proven cryptococcal meningitis.
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