Failure of multiplex meningitis/encephalitis (ME) NAT during cryptococcal meningitis in solid organ recipients.
Benoît PilmisMarie-Elizabeth BougnouxRomain GueryYaye SenghorAlban Le MonnierFanny LanternierStephane BretagneAlexandre AlanioOlivier LortholaryPublished in: Transplant infectious disease : an official journal of the Transplantation Society (2020)
Cryptococcal meningitis is a severe cause of central nervous system infections among immunocompromised solid organ transplant (SOT) patients. While new diagnostic methods as multiplex meningitis/encephalitis (ME) NAT (nucleic acid test) are increasingly used as a first-line tool in hospital practice, data in HIV-negative patients including SOT remain scarce. We report here false-negative results of multiplex NAT among SOT patients with proven cryptococcal meningitis.
Keyphrases
- end stage renal disease
- cerebrospinal fluid
- chronic kidney disease
- ejection fraction
- newly diagnosed
- prognostic factors
- primary care
- healthcare
- nucleic acid
- peritoneal dialysis
- hepatitis c virus
- human immunodeficiency virus
- intensive care unit
- early onset
- antiretroviral therapy
- emergency department
- quality improvement
- patient reported
- hiv positive
- single cell
- drug induced
- data analysis