Hypopurolides A - G, Labdane Diterpenoids from Hypoestes purpurea and Their Nitric Oxide Inhibitory Activity.
Lin-Fen DingBin ChengTie LeiZhen-Xiang LiuXue-Yu ZhaoLiu-Dong SongQin-Shi ZhaoPublished in: Chemistry & biodiversity (2022)
Seven new labdane diterpenoids, hypopurolides A-G (1-7) were discovered from the aerial part of Hypoestes purpurea, along with one known analog, hypopurin D (8). The structures of 1-7 were characterized based on 1 H-, 13 C-, and 2D-NMR, and HR-ESI-MS spectra. The absolute configurations of 1-7 were defined by single-crystal X-ray diffraction and electronic circular dichroism (ECD) data. Compounds 1-8 were tested for their nitric oxide (NO) inhibitory and cytotoxic effects. Compound 6 displayed moderate inhibitory effect toward LPS-induced NO release in RAW 264.7 cells with an IC 50 value of 41.50 μM.
Keyphrases
- nitric oxide
- lps induced
- high resolution
- ms ms
- inflammatory response
- induced apoptosis
- nitric oxide synthase
- mass spectrometry
- hydrogen peroxide
- cell cycle arrest
- solid state
- magnetic resonance
- multiple sclerosis
- electronic health record
- electron microscopy
- high intensity
- density functional theory
- big data
- endoplasmic reticulum stress
- magnetic resonance imaging
- machine learning
- crystal structure
- cell proliferation
- deep learning