Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling.

Sakthivel Muniyan Satyanarayana RachaganiSeema ParteSushanta HalderPrakash KshirsagarJawed A SiddiquiRaghupathy VengojiSanchita RauthRidwan IslamKavita MallyaKaustubh DattaLei XiAnindita DasBenjamin A TeplyRakesh C KukrejaSurinder K Batra

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Our results demonstrate that sildenafil's addition could sensitize docetaxel chemotherapy in prostate cancer cells at much lesser concentration than needed for inducing cell death. Thus, the combinatorial treatment of sildenafil and docetaxel may improve anticancer efficacy and reduce chemotherapy-induced side-effects among patients with advanced prostate cancer.

Keyphrases

prostate cancer
chemotherapy induced
locally advanced
pulmonary hypertension
pulmonary arterial hypertension
cell death
radical prostatectomy
rectal cancer
squamous cell carcinoma
nitric oxide
radiation therapy
cell cycle arrest
combination therapy
smoking cessation
replacement therapy