Association of G6PD variants with hemoglobin A1c and impact on diabetes diagnosis in East Asian individuals.

Aaron LeongVictor Jun Yu LimChaolong WangJin-Fang ChaiRajkumar DorajooChew-Kiat HengRob M van DamWoon-Puay KohJian-Min YuanJost B JonasYa Xing WangWen-Bin WeiJianjun LiuDermot F ReillyTien-Yin WongChing-Yu ChengXueling S Sim

Published in: BMJ open diabetes research & care (2021)

We identified two G6PD variants in East Asian men associated with non-glycemic lowering of HbA1c. Carriers of these variants are more likely to be underdiagnosed for diabetes or pre-diabetes than non-carriers if screened by HbA1c without confirmation by direct glucose measurements.

Keyphrases

type diabetes
glycemic control
cardiovascular disease
copy number
blood glucose
gene expression
blood pressure
middle aged