Glucose-induced cAMP elevation in β-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling.

Hongyan ShuaiYunjian XuParvin AhooghalandariAnders Tengholm

Published in: Acta physiologica (Oxford, England) (2021)

Agonist-independent and glucagon-stimulated GLP1R signalling in β-cells contributes to basal and glucose-induced cAMP production and insulin secretion.

Keyphrases

induced apoptosis
cell cycle arrest
high glucose
diabetic rats
binding protein
blood glucose
endoplasmic reticulum stress
signaling pathway
metabolic syndrome
cell death
type diabetes
endothelial cells
cell proliferation
blood pressure
skeletal muscle
weight loss
insulin resistance