Curcuminoids Inhibit Angiogenic Behaviors of Human Umbilical Vein Endothelial Cells via Endoglin/Smad1 Signaling.

Yi-Fan ChouYu-Hsuan LanJun-Han HsiaoChiao-Yun ChenPei-Yu ChouMing-Jyh Sheu

Published in: International journal of molecular sciences (2022)

The study first showed that Cur and DMC demonstrated antiangiogenic activity via the inhibition of endoglin/Smad1 signaling. Synergistic effects of curcuminoids (i.e., curcumin and DMC) and semaxanib on HUVECs were found. This might be attributed to endoglin/pSmad1 downregulation in HUVECs. Combination treatment with curcuminoids and a semaxanib is therefore expected to reverse semaxanib resistance.

Keyphrases

endothelial cells
epithelial mesenchymal transition
transforming growth factor
cell proliferation
combination therapy
smoking cessation