Meta-analysis of bone mineral density in adults with phenylketonuria.

Júlio César RochaÁlvaro HermidaCheryl J JonesYunchou WuGillian E ClagueSarah RoseKaleigh B WhitehallKirsten K AhringAndré L S PessoaCary O HardingFran RohrAnita InwoodNicola LongoAnia C MuntauSerap SivriFrançois Maillot

Published in: Orphanet journal of rare diseases (2024)

Adults with PKU had lower BMD Z-scores than the reference (non-PKU) population but < 1 in 10 were below the expected range for age. The low number of studies prevents identification of which population characteristics are most impacting BMD. This meta-analysis was supported by BioMarin Pharmaceutical Inc., Novato, CA and is registered with the Research Registry (reviewregistry1476).

Keyphrases

systematic review
bone mineral density
case control
postmenopausal women
meta analyses
body composition
mouse model
protein kinase