Inhibition of Tityus serrulatus venom hyaluronidase affects venom biodistribution.
Bárbara Bruna Ribeiro de Oliveira-MendesSued Eustáquio Mendes MirandaDouglas Ferreira Sales-MedinaBárbara de Freitas MagalhãesYan KalapothakisRenan Pedra de SouzaValbert Nascimento CardosoAndré Luís Branco de BarrosClara Guerra-DuarteEvanguedes KalapothakisCarolina Campolina Rebello HortaPublished in: PLoS neglected tropical diseases (2019)
By comparing TsV biodistribution in the absence or presence of anti-hyaluronidase serum, the results obtained in the present work show that hyaluronidase has a key role not only in the venom spreading from the inoculation point to the bloodstream, but also in venom biodistribution from the bloodstream to target organs. Our findings demonstrate that hyaluronidase is indeed an important spreading factor of TsV and its inhibition can be used as a novel first-aid strategy in envenoming.