Macrophage-derived Wnt signaling increases endothelial permeability during skeletal muscle injury.
S TusavitzS KeoonelaM KalksteinS McCormickB GasserM ArrigaleP RaffertyApril C CarpenterPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)
Our results indicate that macrophage-derived Wnt signaling increases endothelial permeability in a VEGF-dependent fashion following muscle injury. Our findings implicate macrophages as a primary source of Wnt ligands following muscle injury and highlight the Wnt pathway as a therapeutic target following injury.