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RUNX3 alleviates mitochondrial dysfunction and tubular damage by inhibiting TLR4/NF-κB signalling pathway in diabetic kidney disease.
Ling Xiao
Gang Ye
Published in:
Nephrology (Carlton, Vic.) (2024)
SMURF2 interference inhibits RUNX3 ubiquitination and TLR4/NF-κB signalling pathway, thereby alleviating renal tubule injury.
Keyphrases
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signaling pathway
nuclear factor
inflammatory response
lps induced
toll like receptor
oxidative stress
transcription factor
pi k akt
immune response
type diabetes
mouse model
high glucose
cell proliferation
endothelial cells