Novel endosomal NOX2 oxidase inhibitor ameliorates pandemic influenza A virus-induced lung inflammation in mice.

Eunice E ToRaymond LuongJiayin DiaoJohn J O' LearyDoug A BrooksRoss Vlahos Stavros Selemidis

Published in: Respirology (Carlton, Vic.) (2019)

Endosomal NOX2 oxidase promotes pathogenic lung inflammation to IAV infection. The localized delivery of endosomal NOX2 oxidase inhibitors is a novel therapeutic strategy against IAV, which has the potential to limit the pathogenesis caused during epidemics and pandemics.

Keyphrases

oxidative stress
reactive oxygen species
diabetic rats
sars cov
coronavirus disease
type diabetes
drug induced
adipose tissue
metabolic syndrome
insulin resistance