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Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice.

Norihiro ImaiHayley T NichollsMichele Alves-BezerraYingxia LiAnna A IvanovaEric A OrtlundDavid E Cohen
Published in: Hepatology (Baltimore, Md.) (2021)
These results reveal a key role for skeletal muscle Them2 in the pathogenesis of HS and IR and implicate it as a target in the management of NAFLD.
Keyphrases
  • skeletal muscle
  • insulin resistance
  • high fat diet induced
  • genome wide
  • single cell
  • metabolic syndrome
  • adipose tissue
  • transcription factor