Gastrointestinal Involvement in Children with Systemic Lupus Erythematosus.
Angela MauroTeresa GianiClelia Di MariMartina SandiniAntonella TalentiValentina AnsuiniLuigi BiondiGiovanni Di NardoLuca BernardoPublished in: Children (Basel, Switzerland) (2023)
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder. When it presents before the age of 18 years (childhood-onset systemic lupus erythematosus, cSLE), the disease course tends to be more severe with a higher rate of organ involvement and requires an early diagnosis. Gastrointestinal involvement in cSLE is rare and scarcely reported in the literature. Any organ of the gastrointestinal system may be affected, either as a direct consequence of the disease, as a subsequent complication, or as an adverse drug event. Abdominal pain is the most common GI symptom, it can be diffuse or well localized, and can underline different conditions such as hepatitis, pancreatitis, appendicitis, peritonitis, or enteritis. cSLE may have an alteration of the intestinal barrier with features of protein-losing enteropathy or, in genetically predisposed patients, may develop associated autoimmune disorders such as Coeliac Disease or Autoimmune Hepatitis. The aim of this manuscript is to provide a narrative review of gastrointestinal manifestations in cSLE focused on hepatic, pancreatic, and intestinal involvement. A comprehensive literature search based on the PubMed database was performed.
Keyphrases
- systemic lupus erythematosus
- adverse drug
- disease activity
- systematic review
- drug induced
- multiple sclerosis
- end stage renal disease
- abdominal pain
- newly diagnosed
- chronic kidney disease
- ejection fraction
- young adults
- emergency department
- peritoneal dialysis
- rheumatoid arthritis
- patient reported outcomes
- electronic health record
- protein protein
- binding protein