Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation, ANCA-Mediated Endothelial Damage, and Crescentic GN.

Marilina Antonelou Erik MichaëlssonRhys D R EvansChun Jing WangScott R HendersonLucy S K WalkerRobert John UnwinAlan D Salamanull null

Published in: Journal of the American Society of Nephrology : JASN (2019)

Myeloperoxidase inhibition reduced neutrophil degranulation and neutrophil-mediated endothelial cell damage in patients with ANCA-associated vasculitis. In preclinical crescentic GN, delayed myeloperoxidase inhibition suppressed kidney damage without augmenting adaptive immune responses, suggesting it might offer a novel adjunctive therapeutic approach in crescentic GN.

Keyphrases

endothelial cells
oxidative stress
immune response
toll like receptor
dendritic cells
cell therapy
inflammatory response