Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression.
Xinyi GaoShiqi ZhouZhaofu QinDechuan LiYuping ZhuDe-Ning MaPublished in: Journal of translational medicine (2023)
The lactate metabolized by cancer cells stimulated M2 polarization and HMGB1 secretion by macrophages, aggravating the carcinogenic behaviors of cancer cells.