Screening for mouse genes lost in mammals with long lifespans.

Lev I RubanovAndrey G ZaraiskyGregory A ShilovskyAlexandr V SeliverstovOleg A ZverkovVassily A Lyubetsky

Published in: BioData mining (2019)

The method and program, which were applied here to screen for gene losses that can accompany increased lifespan, were also applied to study reduced regenerative capacity and development of the telencephalon, neoteny, etc. Some of these results have been carefully tested experimentally. Therefore, we assume that the method is widely applicable.

Keyphrases

genome wide
stem cells
genome wide identification
high throughput
quality improvement
copy number
cell therapy
dna methylation
gene expression
transcription factor
bone marrow