Oxygen-based autoregulation indices associated with clinical outcomes and spreading depolarization in aSAH.
Andrew P CarlsonThomas JonesYiliang ZhuMasoom DesaiAli AlsarahC William ShuttleworthPublished in: medRxiv : the preprint server for health sciences (2024)
Impairment in autoregulation in aSAH is associated with worse clinical outcomes and occurrence of SD when using ORx and OSRx. Impaired autoregulation precedes SD occurrence. Targeting the optimal MAP or cerebral perfusion pressure in patients with aSAH should use ORx and/or OSRx as the input function rather than intracranial pressure.