Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons.

Mei ZhuGiuseppe P CorteseClarissa L Waites

Published in: BMC biology (2018)

Our findings demonstrate that pathogenic Parkin mutations disrupt glutamatergic synaptic transmission in hippocampal neurons by impeding NMDA and AMPA receptor trafficking. Such effects may contribute to the pathophysiology of PD in PARK2 patients.

Keyphrases

end stage renal disease
spinal cord
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
binding protein