Sex-dependent metabolism of ketamine and ( 2R,6R )-hydroxynorketamine in mice and humans.

Jaclyn N HighlandCristan A FarmerPanos ZanosJacqueline LovettCarlos A ZarateRuin MoaddelTodd D Gould

Published in: Journal of psychopharmacology (Oxford, England) (2021)

Sex is an important biological variable that influences the metabolism of ketamine and the HNKs, which may contribute to sex differences in therapeutic antidepressant efficacy or side effects.

Keyphrases

pain management
major depressive disorder
high fat diet induced
metabolic syndrome
chronic pain
adipose tissue
bipolar disorder
insulin resistance
skeletal muscle