Sirtuin 1 is a potential therapeutic candidate gene for fetal growth restriction via insulin-like 4.

Junya KojimaYidan DaiTomoo SuzukiMasanori Ono Hirotaka Nishi

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2023)

SIRT1 and INSL4 are downregulated in the placenta of FGR, and INSL4 is regulated by SIRT1. These findings indicate that the SIRT1-INSL4 axis may be a potential therapeutic target for FGR.

Keyphrases

oxidative stress
ischemia reperfusion injury
type diabetes
genome wide
copy number
adipose tissue
metabolic syndrome
dna methylation